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de novo lipogenesis, along with downregulating enzymes linked to lipid synthesis, such as ACC and FAS ( in vitro experiment demonstrated that GLP-1RA induces the phosphorylation of Akt, PDK-1, and PKC-, which are key proteins involved in the insulin signaling pathway
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23 The importance of autophagy extends to cardiac development, as evidenced by embryonic lethality and myocardial developmental defects in Atg13-knockout mice, underscoring the indispensable roles of Atg13 and FIP200 in both autophagy and heart formation (Fig
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